Access to 12-Membered Cyclic <i>ortho</i>,<i>meta</i>-Diarylheptanoids: Total Synthesis of Actinidione via Isomyricanone

We describe herein the first access to 12-membered cyclic[7,0]ortho,meta-diarylheptanoids. The key features of synthesis include both a Suzuki-Miyaura coupling and ring closing metathesis. Actinidione, promising natural product, along with bioactive tetracyclic derivative were obtained in 14 steps for time from cheap commercially available substrates an overall yield 18-21%. Our modus operandi complies principles ideality by using notably strategic reactions.